First look: Indianapolis Colts at Tennessee Titans odds and lines

Jess Root
Sportsbook Wire

The Indianapolis Colts (0-2) hope to pick up their first win as they take on the Tennessee Titans (1-1) on the road in an AFC South divisional battle Sunday. Kickoff is set for 1 p.m. ET at Nissan Stadium. Below, we look at the Colts vs. Titans odds and lines; check back for our NFL picks and predictions.

The Colts lost at home for the second week in a row to an NFC West team. They dropped their opener 28-16 to the Seattle Seahawks and fell 27-24 to the Los Angeles Rams in Week 2. QB Carson Wentz had a touchdown pass and an interception, and Jacob Eason, replacing an injured Wentz, threw a back-breaking interception after the Rams took a 27-24 lead.

The Titans bounced back from a Week 1 loss to defeat the Seattle Seahawks 33-30 on the road in overtime. RB Derrick Henry exploded for 182 rushing yards and 3 touchdowns after being held to 58 yards in their opener. Tennessee rallied from a 30-16 fourth-quarter deficit to win the game.

Colts at Titans odds, spread and line

Odds provided by Tipico Sportsbook; access USA TODAY Sports' betting odds for a full list. Lines last updated Monday at 2:27 p.m. ET.

  • Money line: Colts +190 (bet $100 to win $190) | Titans -240 (bet $240 to win $100)
  • Against the spread (ATS): Colts +5.5, -108 (bet $108 to win $100) | Titans -5.5, -112 (bet $112 to win $100)
  • Total (O/U): 48.5, Over -108 (bet $108 to win $100) | Under -112 (bet $112 to win $100)

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2021 betting stats:

  • ML : Colts 0-2 | Titans 1-1
  • ATS : Colts 1-1 | Titans 1-1
  • O/U : Colts 1-1 | Titans 1-1

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Colts at Titans head-to-head

These division rivals face each other twice a year. The Colts have a 35-18 lead all-time over the Titans dating back to 1970.

Henry had 178 rushing yards and 3 touchdowns as he led the Titans to a 45-26 win in their last meeting in 2020.

The Colts have won the last three matchups in Tennessee and are 8-1 there since 2012. They beat the Titans 34-17 last season when they met in Tennessee.

Conversely, the Titans have won three of the last four games in Indianapolis.

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