The M&T Bank at 643 E. Baltimore St., Greencastle, was robbed late Tuesday morning.
Greencastle police said a white man entered the bank at 11:43 a.m., demanded money and left with an undisclosed amount out cash.
No weapon was displayed and no injuries were reported.
Greencastle police are continuing the investigation with the assistance of Pennsylvania State Police.
Anyone with information is asked to call Greencastle police at 717-597-2161.
It is the second robbery in Greencastle in less than a week. The Family Dollar at 118 S. Antrim Way was robbed by a man wielding a knife Friday evening, July 28.
Greencastle police said the robber, a white male, entered the store, shopped for merchandise and held the cashier up with a knife. He took all the cash from a register, left the merchandise behind and fled on foot.